Found 24 matching trials
Influence of Mild and Moderate Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of Various Doses of Afatinib PHASE1 Up to 38 subjects entered with the aim of entering 8 subjects with mild liv...
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1200.86.1 Boehringer Ingelheim Investigational Site
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LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy PHASE3 This randomized, open-label, phase III study will be performed in patients ...
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Beijing Chao-Yang Hospital
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A Phase I/II Study Afatinib/Carboplatin/Paclitaxel Induction Chemotherapy In HPV-Negative HNSCC. PHASE1 Trial Objectives:
The objective is to investigate the efficacy and safety ...
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
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Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations PHASE3 Global, Phase 3, randomized, multicenter, open-label study evaluating the e...
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St. Jude Medical Center
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Afatinib and Cetuximab in Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Positive Non-small-cell Lung Cancer PHASE2 This is a single arm open-label multi-center phase II study, investigating ...
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Antoni van Leeuwenhoek
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Drug Interaction Study With Rifampicin and Afatinib PHASE1 The objective of the current study is to investigate the effect of the P-gp...
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1200.152.1 Boehringer Ingelheim Investigational Site
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Safety and Tolerability of 4 Different Dosage Strengths of BIBW 2992 Tablets to Healthy Male Volunteers PHASE1 Study to assess pharmacokinetics incl. dose proportionality, safety and tol...
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Multiple Locations
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Investigation of Ritonavir Effects on Afatinib Exposure in Healthy Subjects PHASE1 To study the effect of the P-glycoprotein inhibitor ritonavir on the pharma...
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1200.151.1 Boehringer Ingelheim Investigational Site
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XH-30002 Capsule Combined With Afatinib Tablets for the Treatment of Squamous Cell Carcinoma PHASE1 This study is an exploratory clinical trial and does not involve statistica...
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Multiple Locations
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Afatinib and Pembrolizumab for Head and Neck Squamous Cell Carcinoma (ALPHA Study) PHASE2 The primary objectives of the trial is to examine the toxicities and effica...
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National Taiwan University Hospital
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